File:Proton pump inhibitors structure.svg

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English: Common structure of proton pump inhibitors. Asterisk indicates stereocenter. Dots indicate lone pair.
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來源 自己作品
作者 Anypodetos
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Public domain This image of a simple structural formula is ineligible for copyright and therefore in the public domain, because it consists entirely of information that is common property and contains no original authorship.
Compound Substituents Form Cysteine binding pKa First approval
X R1 R2 R3 R4 pKaa1 pKaa1 year
Omeprazole CH OCH3 CH3 CH3 CH3 Racemic mixture 813 and 892 4.06 0.79 1989 in USA
Esomeprazole CH OCH3 CH3 CH3 CH3 (S)-(−)-enantiomer of lansoprazole 813 and 892 4.06 0.79 2001 in USA
Lansoprazole CH H CH3 CH2CF3 H Racemic mixture 813 and 321 3.83 0.62 1991 in Europe
Dexlansoprazole CH H CH3 CH2CF3 H (R)-(+)-enantiomer of lansoprazole 813 and 321 3.83 0.62 2009 in USA
Pantoprazole CH OCHF2 OCH3 CH3 H Racemic mixture 813 and 822 3.83 0.11 1994 in Germany
Rabeprazole CH H CH3 (CH2)3OCH3 H Racemic mixture 813, 892 and 321 4.53 0.62 1999 in USA
Tenatoprazole N OCH3 CH3 CH3 CH3 Racemic mixture 813 and 822 4.04 –0.12
 
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Creative Commons CC-Zero This file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication.
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7 2 2012

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現時2015年12月7號 (一) 12:11響2015年12月7號 (一) 12:11嘅縮圖版本512 × 227(10 KB)Vaccinationistfacelifting
2012年2月8號 (三) 19:05響2012年2月8號 (三) 19:05嘅縮圖版本275 × 135(35 KB)AnypodetosMark stereocenter
2012年2月7號 (二) 14:31響2012年2月7號 (二) 14:31嘅縮圖版本275 × 135(34 KB)Anypodetos{{Information |Description ={{en|1=Common structure of {{w|proton pump inhibitor}}s}} |Source ={{own}} |Author =Anypodetos |Date =2012-02-07 |Permission = |other_versions = }} {{BKchem}}{{Inkscape}} [[C

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