組胺酸脫羧酶

出自維基百科,自由嘅百科全書
跳去: 定向搵嘢

組胺酸脫羧酶(學名histidine decarboxylase,減筆HDC)係一種,佢夾埋維他命乙,將組胺酸轉成組織胺二氧化碳[1][2][3]。過程如下:

C₆H₉N₃O₂C₅H₉N₃ + CO₂

組胺酸脫羧酶將組胺酸轉成組織胺

人嘅遺傳基因當中,收埋咗造組胺酸脫羧酶嘅圖樣。 [4][5]

生理上,組織胺係隻重要嘅神經傳遞neutrotransmission),胃酸分泌,平滑肌舒張,都係靠佢。要有組織鞍,就要靠左旋組胺酸脫羧酶( L-histidine decarboxylase),將組鞍酸化成組織鞍。[4]

組織胺亦負責擴大組織通道,畀白血球過去打仗。如果組織胺太多,就會襲擊身體各處發炎,即係敏感症好似哮喘濕疹。其中一個醫法,就係唔畀組胺酸脫羧酶造咁多組織胺。例如食五羥黃酮嘅嘢,係制呢隻酶。

生嘅有唔少組胺酸,如果無住,佢周圍嘅組胺酸脫羧酶,就發揮功用,將佢哋變成組織鞍。人食咁多組織鞍,就打亂身體反應,就好似過敏症,中晒毒咁。有啲魚肉零舍多組胺酸,唔過唔可以做魚生

[編輯]

  1. Epps HM (1945). "Studies on bacterial amino-acid decarboxylases: 4. l(-)-histidine decarboxylase from Cl. welchii Type A". Biochem. J. 39 (1): 42–6. PMC 1258146free to read. PMID 16747851. 
  2. Riley WD, Snell EE (1968). "Histidine decarboxylase of Lactobacillus 30a. IV. The presence of covalently bound pyruvate as the prosthetic group". Biochemistry. 7 (10): 3520–8. PMID 5681461.  未知參數|month=已忽略 (詳情)
  3. Rosenthaler J, Guirard BM, Chang GW, Snell EE (1965). "Purification and properties of histidine decarboxylase from Lactobacillus 30a". Proc. Natl. Acad. Sci. U.S.A. 54 (1): 152–8. PMC 285813free to read. PMID 5216347.  未知參數|month=已忽略 (詳情)
  4. 4.0 4.1 "Entrez Gene: histidine decarboxylase". 
  5. Bruneau G, Nguyen VC, Gros F, Bernheim A, Thibault J (1992). "Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15". Hum. Genet. 90 (3): 235–8. PMID 1487235.  未知參數|month=已忽略 (詳情)

參攷[編輯]

  • Need AC, Keefe RS, Ge D; 等 (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.". Eur. J. Hum. Genet. 17 (7): 946–57. doi:10.1038/ejhg.2008.264. PMID 19156168. 
  • Masini E, Fabbroni V, Giannini L; 等 (2005). "Histamine and histidine decarboxylase up-regulation in colorectal cancer: correlation with tumor stage.". Inflamm. Res. 54 Suppl 1: S80–1. doi:10.1007/s00011-004-0437-3. PMID 15928846. 
  • Li Z, Liu J, Tang F; 等 (2008). "Expression of non-mast cell histidine decarboxylase in tumor-associated microvessels in human esophageal squamous cell carcinomas.". APMIS. 116 (12): 1034–42. doi:10.1111/j.1600-0463.2008.01048.x. PMID 19133005. 
  • Szafranski K, Schindler S, Taudien S; 等 (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMID 17672918. 
  • Ai W, Liu Y, Langlois M, Wang TC (2004). "Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements.". J. Biol. Chem. 279 (10): 8684–93. doi:10.1074/jbc.M308278200. PMID 14670968. 
  • Raychowdhury R, Fleming JV, McLaughlin JT; 等 (2002). "Identification and characterization of a third gastrin response element (GAS-RE3) in the human histidine decarboxylase gene promoter.". Biochem. Biophys. Res. Commun. 297 (5): 1089–95. PMID 12372397. 
  • Kimura K, Wakamatsu A, Suzuki Y; 等 (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Sköldberg F, Portela-Gomes GM, Grimelius L; 等 (2003). "Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells.". J. Clin. Endocrinol. Metab. 88 (4): 1445–52. PMID 12679420. 
  • Brew O, Lakasing L, Sullivan M. "Differential activity of histidine decarboxylase in normal and pre-eclamptic placentae.". Placenta. 28 (5-6): 585–7. doi:10.1016/j.placenta.2006.05.003. PMID 16822545. 
  • Zhang F, Xiong DH, Wang W; 等 (2006). "HDC gene polymorphisms are associated with age at natural menopause in Caucasian women.". Biochem. Biophys. Res. Commun. 348 (4): 1378–82. doi:10.1016/j.bbrc.2006.08.008. PMID 16919600. 
  • Tippens AS, Gruetter CA (2004). "Detection of histidine decarboxylase mRNA in human vascular smooth muscle and endothelial cells.". Inflamm. Res. 53 (6): 215–6. doi:10.1007/s00011-004-1252-6. PMID 15167966. 
  • Siezen CL, Bont L, Hodemaekers HM; 等 (2009). "Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.". Pediatr. Infect. Dis. J. 28 (4): 333–5. doi:10.1097/INF.0b013e31818e2aa9. PMID 19258923. 
  • Morgan TK, Montgomery K, Mason V; 等 (2006). "Upregulation of histidine decarboxylase expression in superficial cortical nephrons during pregnancy in mice and women.". Kidney Int. 70 (2): 306–14. doi:10.1038/sj.ki.5001553. PMID 16760908. 
  • Papadopoulou N, Kalogeromitros D, Staurianeas NG; 等 (2005). "Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria.". J. Invest. Dermatol. 125 (5): 952–5. doi:10.1111/j.0022-202X.2005.23913.x. PMID 16297195. 
  • Janssen R, Bont L, Siezen CL; 等 (2007). "Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.". J. Infect. Dis. 196 (6): 826–34. doi:10.1086/520886. PMID 17703412. 
  • Strausberg RL, Feingold EA, Grouse LH; 等 (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Aichberger KJ, Mayerhofer M, Vales A; 等 (2006). "The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells.". Blood. 108 (10): 3538–47. doi:10.1182/blood-2005-12-028456. PMID 16849647. 
  • Lee JK, Kim HT, Cho SM; 等 (2003). "Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.". J. Hum. Genet. 48 (5): 213–6. doi:10.1007/s10038-003-0011-9. PMID 12768436. 
  • Jeong HJ, Moon PD, Kim SJ; 等 (2009). "Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression.". Cell. Mol. Life Sci. 66 (7): 1309–19. doi:10.1007/s00018-009-9001-1. PMID 19266161. 

出面網頁[編輯]